Zhehui Wang P-25, LANL An expert system for proton radiography Enrico Fermi had the honor of being the last physicist who knew all the physics there was to know. As time progresses, it may be anticipated that any sub-field of physics, such as proton radiography, will become so complex and rich in information that it is impossible for any single person to comprehend. We need an evolving computer-based expert system on proton radiography (and in the same vein, any accumulative effort) to charter what we have already known, avoid duplicate discoveries, and guide future growth of the field. Indeed, it may be difficult to have a full comprehension of the field even now, considering that a successful proton radiography experiment requires flawless integration of the accelerator, different diagnostics, the Line-C dome facility, data acquisition system, and timely analysis of the results, besides the underlying physical principles and various databases. In this talk, I will present some existing thoughts and developments of an expert system for other fields and then discuss how to implement them for proton radiography. Besides providing a steady source of knowledge base for new comers, other possible benefits or uses of an expert system include designing and planning of a new experiment, minimizing the time between initiation of a new idea and generation of the experimental data, and identifying new experimental opportunities.