Heavy shielding can render active interrogation of cargo useless. This shielding attenuates both the probe and product particles. The product of these two attenuation factors can make detection impossible. Intermediate energy protons produce fissions as effectively as neutrons or high energy gamma rays but are much more penetrating than either of these convention probes. We have: 1) Performed experimental measurements of delayed gamma rays and neutrons produced by proton interactions with a wide range of targets; 2) used these data to validate Monte Carlo studies; and 3) Studied accelerator designs and costs for a system that might be used for proton interrogation.