Title: Design and Optimization of Li-6 Neutron-Capture, Pulse Mode Ion Chamber Abstract: The purpose of this ongoing research is to design and optimize the performance of a unique, inexpensive 6Li neutron-capture, pulse mode ion chamber (LiPMIC) for neutron detection that can overcome the fill-gas contamination stemming from outgas of detector parts. This research will also provide a demonstration of performance of LiPMICs. Simulations performed with Garfield, a drift-chamber simulation package for ion transport in an electrostatic field, have shown that certain mixtures of fill-gas allow maintaining similar electron drift velocity through a surprisingly wide range of fill-gas content. This novel pulse-mode ion chamber is specifically designed as one of several cost-effective instruments that have the potential to fulfill the needs for large-scale deployment in a distributed network of remote sensors. The detector is expected to provide non-invasive interrogation of goods and personnel at borders, ports, strategic landmarks, and buildings for detecting nuclear materials such as plutonium. The LiPMIC is expected to provide neutron detection capability for deployment for homeland security and nuclear material control and accountability applications at the comparable performance level to the currently available neutron detectors, such as 3He proportional counters, while reducing the initial procurement cost by an order of magnitude.